Flow Chemistry
Hande Sciences has flow chemistry experience in:
- Safety: Azidations, Nitrations, Oxidations, High Temperature Rearrangements, Halogenations via Diazonium Salts and Curtius Rearrangements
- Scalability: Photocatalytic Brominations, Asymmetric Hydrogenation (or other reactive gases)
- Reaction Control: Oxidation, Reductions, Lithiations, Grignard, Formulations and Rearrangements
Other Information:
- Modular Equipment:Coil Reactors, Column Reactors, CSTR, Corning G1 Continuous Flow Reactor Platform, Photochemical Reactor, Fixed-bed Reactor; TCU; Centrifuge Extractor
- Temperature Range:-80 to 300 oC
- Pressure Range: 0 to 4 MPa (40 bar)
- Flow Rate: Minimum flow rate during development: 20 μL/min.Maximum flow rate during manufacturing: 3 L/min.
High-Throughput Screening: Crystallization Screening
High-Throughput Screening: Crystallization Screening
High-Throughput Screening: Crystallization Screening
Hande Sciences has reagent kits (chiral and achiral carboxylic acids and amines, and solvents) and facilities for fast crystallization screening, including classical resolution:
- High through-put screening.
- Analytical: HPLC (purity and mass balance (by assay)), XRPD, Polarized Light Microscopy, DSC.
- Rapid technology transfer to PR&D and scale-up.
Catalyst Screening
High-Throughput Screening: Crystallization Screening
High-Throughput Screening: Crystallization Screening
Hande's screening program offers parallel screening for time and cost efficient identification of reagents and conditions. High through-put screening.
- Analytical: HPLC (purity and mass balance (by assay)), XRPD, Polarized Light Microscopy, DSC.
- Rapid technology transfer to PR&D and scale-up.